Cannabidiol (CBD) health and wellness products are popular among its users due to their therapeutic benefits like analgesic, anti-inflammatory, anxiolytic, anticonvulsive, antiemetic, and neuroprotective effects. One of the most popular choices for medical uses is CBD oil, and this is because of its versatility, i.e. you can easily adjust the dosage based on your changing requirements. In this article, we will focus on the importance of bioavailability in CBD oil dosage, read on to know more about it.
What Is Bioavailability?
Bioavailability is the amount of cannabidiol available to the body after consuming a dose of CBD oil. This primarily depends on the method of consumption and affects the quality of CBD benefits experienced by you. Among the different methods of consuming cannabidiol, inhaling has the highest bioavailability because it directly enters the bloodstream through the highly permeable alveoli of the lungs. This is followed by sublingual consumption of CBD tinctures, here CBD enters the bloodstream through the tiny blood vessels under the tongue. Oral consumption of CBD oil has the lowest bioavailability because it must pass through the digestive system to be absorbed into the bloodstream.
What Is The Pharmacokinetics Of CBD Oil During Oral Consumption?
When you consume CBD oil or products made using it like pills and capsules, it must pass through the digestive system. Here, it is broken down and absorbed into the bloodstream through the intestinal villi. During this process, a portion of the cannabidiol contained in the dose of CBD oil is eliminated and is wasted. The CBD absorbed into the bloodstream is carried to the liver through the hepatic portal vein.
In the liver, CBD is metabolized by a group of enzymes called cytochrome PY450 (CYP450) into constituent metabolites, some are useful, while others are not. The useful metabolites become available to the endocannabinoid system (ECS) of the body to produce therapeutic effects of CBD, while the unusable metabolites are eliminated out of the body. This process is called the first-pass metabolism, and it reduces the amount of cannabidiol available to the body in a dose of CBD oil. This is the reason for the lower bioavailability of CBD oil during oral consumption.
How To Increase The Bioavailability Of CBD Oil?
To increase the bioavailability of CBD oil, manufacturers have come up with a process called nanoemulsion. Here, CBD oil drops are broken down into nanoparticles so that they mix with water and is easily absorbed into the body because of the smaller particle size. As a result, you require a lower dosage of CBD oil to get the same effects compared to the regular product.
It is obvious by now that bioavailability plays an important role in CBD oil dosage and influences the price per dose of CBD oil.